Additionally, GLP-1 receptor agonists act on appetite-regulating centers in the hypothalamus, reducing hunger signals and promoting weight loss
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However, in some circumstances, hemostatic signaling becomes dysregulated and excessive blood clotting or abnormal clots that obstruct blood flow can form
The landmark SURMOUNT-1 trial demonstrated that participants receiving the highest dose of tirzepatide lost up to 22.5% of their total body weight over 72 weeks