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Furthermore, to gain deeper insights into the transition from skin psoriasis to PsA, it will be important to include a subgroup of patients with PsA without pre-existing skin involvement

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( b ) Immunoblot of the indicated proteins in cells transduced with shRNA targeting IDH1 (shIDH1) and supplemented with KG, l-carnitine (l-Carn), or O-acetyl-l-carnitine (Ac-Carn)

Skin health reflects multifactorial influences, and comprehensive approaches combining appropriate skincare, sun protection, nutrition, and lifestyle factors provide the foundation for optimal skin appearance

PUFAs can modulate pathways in T and B cells, as observed in preclinical models

Once the desired experimental outcome is achieved (e.g., a certain level of pigmentation), the protocol should shift to a maintenance phase