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In fact, major scientific reviews agree that, while the diuretic effect may decrease with habitual use, humans do not develop tolerance to the far more dangerous central nervous system effects.29 3031 Still, caffeine apologists can cite research where coffee drinkers were given caffeine and their blood pressure did not increase

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For many SSRI and other new-generation antidepressant drugs, a relationship between plasma concentrations and clinical effects is not reported [5]

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