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Researchers have noted a complex interplay between the ECS and the hypothalamus, pituitary gland, and the ovarian axis, with CB1 receptors the primary receptors of the ECS believed to modulate numerous aspects of physical and sexual development

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If this occurs with the 4mg gum (or stronger), consider dropping down to the 2mg nicotine chewing gum to reduce these side effects

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Otero CE, Noeker JA, Brown MM, Wavreil FDM, Harvey WA, Mitchell KA, Heggland SJ