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Regional Insights Asia-Pacific remains the largest and most influential region in the global market, accounting for a substantial share of global consumption and revenue

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As tolerance builds, the brain requires increasing amounts of nicotine to produce the same effect

After removing rs1229984 and re-running all analyses, the resulting estimate was only slightly attenuated towards the null, and the point estimate remained in the same direction [0.84 (95% CI 0.631.11