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The Protein Preparation Wizard was used to assign bond orders, add hydrogens, generate zero-order bonds to metals, and correct missing side chains or loops when required

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Gene expression (4,000+ genes) A 2018 review of Broad Institute Connectivity Map data reported that GHK modulates the expression of more than 4,000 human genes, spanning collagen synthesis, DNA repair, antioxidant defense, and anti-inflammatory pathways (Pickart & Margolina, International Journal of Molecular Sciences, 2018)

MariTide differentiates itself from other GLP-1 medications by using a monoclonal antibody formulation that permits monthly administration, as opposed to the more common weekly dosing schedule