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Ultimately, elucidating the mechanisms that govern transitions between protective and pathological states will be critical to refine classification systems and to guide therapeutic strategies targeting astrocyte reactivity

Ckmt1-KO and WT mice on a C57BL/6N background were maintained at the University of Guelph as previously described 47

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Theres no meaningful clinical advantage to more expensive forms like creatine hydrochloride or buffered creatine for most people, despite marketing claims to the contrary

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Effects of dalcetrapib in patients with a recent acute coronary syndrome