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Approximately 865,000 Marylanders use tobacco and electronic smoking devices, most of them starting before age 21

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Given the large number of studies included in the meta-analysis, our findings can serve as a valuable reference for future research regarding effect size

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To further support this finding is the fact that in female offspring, the alterations in methacholine responsiveness disappeared by 60 wk of age but reappeared on reexposure to CS, suggesting that early-life CS exposure alone may not be enough to induce life-long lung function alterations but may prime the lungs so that on reexposure to CS, lung function is altered