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75 In animal studies, CCL5 functions as an essential component of the crosstalk between BC and tumor microenvironment cells by: (1) modifying the balance of various leukocytes, in situ, via enhanced recruitment of deleterious TAMs and the suppression of antitumor T cell activity

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The meta-analysis showed higher rates of CV endpoints in patients on CHANTIX relative to placebo across different time frames and pre-specified sensitivity analyses, including various study groupings and CV outcomes