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21 For information about the impact of e-cigarette use on CVD risk see page 4 E-cigarettes and the heart. Smoking, Mortality and Life Expectancy Throughout the first half of the 20th century the hazards of smoking remained largely unsuspected

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Fentanyl has been increasingly present in other opioid-based and non-opioid illicit substances (e.g., stimulants) since 2013[13], causing unintentional use by persons who are unaware of fentanyl adulteration in their drug supply