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In terms of improving obstructive lung physiology among smokers of combustible cigarettes who have switched completely to e-cigarettes, there are conflicting results: one study showed improved spirometry;[5] two others showed no changes.[60,61] Overall, the data suggest that e-cigarette use is potentially associated with early obstructive pulmonary changes, but this association remains inconclusive

Cardiovascular dysautonomia as well as allodynia and sleep disturbance were less frequent (~ 15%)

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