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In ME/CFS, anti-inflammatory bacterial species such as Faecalibacterium (191, 194) and Bifidobacterium (191) are decreased, resulting in a decreased production of anti-inflammatory butyrate (191, 194)

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For example, the p values were less than 0.05 for comparisons of the results obtained with 50 mg of sildenafil and 10 mg of IN PT-141 to each of 50 mg of sildenafil alone, 100 mg of sildenafil alone, 7 mg of IN PT-141 alone (in normal human volunteers)and 10 mg of IN PT-141 alone (also in normal human voltuneers)

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