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Potent incretin-based therapies reduce appetite and energy intake, but inadequate dietary quality during rapid weight loss may increase risk of lean mass loss, micronutrient inadequacy, constipation, gallstone symptoms, and treatment discontinuation

It also plays a role in insulin secretion and fat metabolism

doi:10.1016/j.cell.2016.08.064 200

Sudden dose escalation increases the likelihood of nausea and vomiting

NexLife is a telehealth platform, not a medication

Thus, the decreased cardiorenal risk associated with the combined use of GLP1-RAs/SGLTis may be attributed to an additive effect, achieved by the distinct mechanisms and sites of action for these different drug classes [13]