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When this ratio collapses, the cell enters a state of severe oxidative stress, leading to accelerated aging, mitochondrial dysfunction, and eventually, cellular death (apoptosis)

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Neuro-Endocrinol Lett 30:4629 Aboul-Fotouh S (2013) Coenzyme Q10 displays antidepressant-like activity with reduction of hippocampal oxidative/nitrosative DNA damage in chronically stressed rats