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Researchers have been trying to develop molecules called antagonists to block CB1's function in conditions in which the receptor is overactive, like obesity, but until now the use of the antagonists has been thwarted by psychiatric side effects including mood disorders and anxiety arising from their activity in the brain

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While Toby Huss can't perfectly recreate Johnny Hardwick's voice, it's still good that an original King of the Hill actor got the part

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