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For muscle NAD + and other correlation analyses, the data collected during our previous study 27 was revisited

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Viral nsp12 could alter AA metabolism (especially of the branchedchain amino acids , BCAA), while nsp12, nsp7 , and nsp8 interactions with electron transport chain (ETC) and ribosomal proteins could potentially dysregulate mitochondrial respiration 39

This broad-spectrum neutralization halts the chain reactions of oxidative damage that destroy cellular proteins and mutate DNA