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There is evidence that indicates that the increase in RONS concentration is a inducer of tissue damage, activation of microglia and astrocytes, neuronal dysfunction, neurodegeneration and cell death (Federico et al., 2012

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This infiltrate is particularly relevant in the context of aging, where dysregulated meningeal immunity may exacerbate neuroinflammation and contribute to cognitive decline [151]

Many factors can deplete the amount of glutathione in your body, including pollution, stress, infections, poor sleep, a diet low in plant foods, and even simply becoming older, as youll make less of this valuable antioxidant as you age