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Research has shown that SGLT2 inhibitors benefit patients with and without type 2 diabetes mellitus (T2DM) by reducing proteinuria and slowing the progression of CKD (239, 281)

Semaglutide delivers 14.9% body weight loss in STEP-1 (4,500+ patients)

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To determine their supposed roles in cardiac glycoside biosynthesis in milkweed, these genes of interest will be targets for silencing using Agrobacterium -mediated transformation harboring RNAi constructs containing our gene(s) of interest