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The assessment of malondialdehyde (MDA) levels revealed that the OGD/R group had significantly higher MDA levels compared to the control group

Total RNA was isolated using TRIzol Reagent (Invitrogen, Breda, The Netherlands)

This risk posits a critical limitation on the therapeutic window for senolytic drugs like FOXO4-DRI, demanding a fine balance between efficacy and safety

[85] [86] Even if such data are interesting from a scientific point of view, the application in the clinical routine of a prognostic model based on specific genotypes is still not possible

Furthermore, a study conducted on human retinal cells (ARPE-19) exposed to sources of oxidative stress, such as hydrogen peroxide (HO) or UVB rays, demonstrated that each molecule has a distinct antioxidant effect

Thioredoxin and thioredoxin target proteins: From molecular mechanisms to functional significance