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[26] It was believed that tobacco was a gift from the Creator [27] and that the exhaled tobacco smoke was capable of carrying one's thoughts and prayers to the Great Spirit

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Biological factors play a significant role in the development of tobacco addiction, primarily through the effects of nicotine on the brain

Notably, a Korean casecontrol study identified both active and passive smoking as independent risk factors for PBC (OR: 2.03

Deliver about 0.6 mg of nicotine each