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3.4 Limitations of stimuli-responsive nanoparticle designs Stimuli-responsive NP systems, including those triggered by pH, enzymatic activity, or ROS, depend on pathological thresholds that vary widely among patients, disease locations, and inflammatory states (Barros et al., 2026)

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It also said the nicotine content of both heated tobacco sticks and cigarettes is of low relevance to consumers, pointing out the differences between nicotine content, emissions and exposure (the amount absorbed by the user)

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