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In February 2025, Japan Tobacco Inc

Besides, exposure to tobacco smokeboth active and passive exposure to traditional cigarettesduring pregnancy can cause negative maternal and neonatal outcomes, such as infertility, low birth weight, preterm birth, antepartum and intrapartum stillbirth and perinatal birth [13]

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These findings indicate that environmental exposure, such as exposure to cigarette smoke, modulates disease risk and progression through intricate interactions with genetic factors such as GPR15, thereby influencing disease susceptibility and phenotype