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There is evidence for both of these explanations

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In general, exposure to pollutants induces pulmonary inflammation through the generation of oxidative stress 12,13 , defined as the imbalance in reactive oxygen species production, to the detriment of the antioxidant defence systems 14

In a COPD mouse model, CS exposure led to endoplasmic reticulum stress, mitochondrial damage, and increased NLRP3 inflammasome formation

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