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In the absence of MTAP, the substrate methyl thionyl adenosine (MTA) accumulates and acts as a selective inhibitor of PRMT5 to inhibit PRMT5 methylation activity, 237 whereas MAT2A can produce the PRMT5 substrate SAM, 238 allowing PRMT5 to exert its oncogenic effect

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In some embodiments, the otic composition or formulation comprises less than 2% by weight of water

So, you get better brightening results than either can provide alone

J., Haigis, M

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