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So what does science say about it

Method of Use: Dosage and duration of treatment should be supervised by a healthcare professional, adapting to the severity of each case (e.g., diabetic neuropathy or sciatica)

That conversion step can slow absorption, especially in people with certain metabolic conditions

This is also why you might notice that diets and exercises that worked for you in the past do not work as well or at all later in life

Three to four weeks People with good absorption may still experience benefits, though many improvements linked to deficiency settle down sooner

Additionally, vitamin B12 is important for energy production