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"Early, aggressive treatment to achieve remission is the primary goal of therapy and can be best achieved early on when treating patients with newly diagnosed rheumatoid arthritis, as early disease control is associated with improved long-term outcomes," said Vivian Bykerk, senior investigator and director of the Inflammatory Arthritis Centre of Excellence at Hospital for Special Surgery

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The authors suggest that combustion of the leaf wrapper contributes substantially to the formation of highly reactive particles

New York: Hyperion

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As Carnival's smoking policies gradually became more restrictive, Alfred's was closed to cigar smokers, who were then banished to a smaller bar named Vincent's, near the back of the ship