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Adjustment should be systematic rather than reactive

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The appeal stems from a fundamental biological advantage

AKB-6548, a new hypoxia-inducible factor prolyl hydroxylase inhibitor increases hemoglobin while decreasing ferritin in a 28-day, phase 2a dose escalation study in stage 3 and 4 chronic kidney disease patients with anemia [abstract]

Nonetheless, further investigations are warranted to fully elucidate the underlying mechanisms and optimize the treatment protocol for maximal clinical benefit