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In line with the hypothesis that epithelium from control smokers is better protected against cigarette smoke-induced changes in mitochondrial function, OXPHOS complex levels were not (persistently) higher in PBECs from smokers with normal lung function than from never-smokers, although OXPHOS complex II, III and VF1 were increased upon long-term CSE exposure in BEAS-2B

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Studies were deemed high quality on MMAT, CONSIDER, or MORI if they met 50% of the relevant criteria, consistent with previous reviews recently undertaken [17, 20]

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