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First, these trials provided smoking cessation counseling to all subjects, an important level of support that may not be routinely available to many patients in usual clinical practice

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The above-noted reports provided evidence of reduced levels of HPHCs in e-cigarette aerosols compared to cigarette smoke, others have raised concerns about the levels of carbonyl compounds such as acetaldehyde, acrolein, and formaldehyde in aerosols generated by heating e-liquids, as well as metals that may be released from the device components [8, 54, 55]