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mtROS are generated by inefficient electron transfer through the ETC 104 , and defects in the ETC have been shown to increase mtROS even further 105

Serious complications happen rarely

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28 When DNA repair pathways become disrupted, particularly those involving base excision repair and nucleotide excision repair, accumulated DNA damage triggers p53-mediated responses, which can induce cell cycle arrest, apoptosis, or premature differentiation of MSCs, directly contributing to the graying phenotype