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When we controlled for post-scan withdrawal symptoms between change in DMN connectivity and nicotine dose, there was no significant partial correlation ( r = 0.17, test statistic = 0.35, p = 0.75)

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Finally, as our analysis is observational, causal inferences between UHR, BMI, and stroke cannot be definitively established

The American Psychiatric Association notes, "People with substance use and behavioral addictions are aware of their problem but not able to stop even if they want and try to." The effects of drug addiction lead to severe health complications, including cardiovascular disease, stroke, cancer, HIV/AIDS, hepatitis B and C, lung disease, and mental disorders