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In the natural aging + FOXO4-DRI group, mice received intraperitoneal injections of FOXO4-DRI (5 mg/kg, MCE, HY-P4157) every 2 days during the same period, followed by tissue collection

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Appetite suppression and reduced food intake are primarily driven by GLP-1RAs through three synergistic mechanisms

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Hence, we cannot prove that retatrutide directly stimulated the sinus node in the human heart but only present evidence in mouse right atrial preparations for a positive chronotropic effect of retatrutide in a companion paper and in abstract form (Neumann et al