A study that looked at coffee brewed without a filter (such as French press) found that dark roast coffee contained slightly less of a substance called cafestol than lighter roasts
Results Association of peptide proteoforms with age, sex and post-mortem interval Nontryptic mass spectrometry was performed on 102 human cortical samples obtained post-mortem from the angular gyri of individuals stratified into four diagnostic classes: neuropathological AD diagnosis with dementia (dementia, 25 participants), neuropathological AD diagnosis without dementia (resilient, 25 participants), no AD or other neurological disease diagnosis with dementia (frail, 26 participants), and a control group with no AD or other neurological disease diagnosis and negligible cognitive decline at time of death (control, 26 participants)
A., Horner, J
ACS Med Chem Lett (2019) 10(8):12227
The strongest data to support the safety of epithalon comes from two 3-year epithalamin treatment trials in elderly adults, one of which had a 12-year follow-up [1, 12]
Chemical research in toxicology, 2007, 20(9): 1309- 1314
