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Dekker I, van der Leest M, van Rijk MC, Gerritsen WR, Arens AIJ

(2014) The glutathione synthesis inhibitor buthionine sulfoximine synergistically enhanced melphalan activity against preclinical models of multiple myeloma, Blood Cancer J

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Although the impairment of autophagy in DKD is widely accepted, the regulation of autophagy and its underlying mechanism are still not fully understood

Its mechanism involves activating the AMPK/SIRT1 pathways and suppressing lipogenic regulators like PPAR and SREBP-1c, highlighting its potential as a therapeutic candidate for NAFLD (96)