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It catalyzes the esterification of long-chain polyunsaturated fatty acids (PUFAs, (e.g., arachidonic acid) into membrane phospholipids, making them substrates for peroxidation by enzymes like lipoxygenases (ALOXs) ( 2+ , is an essential catalyst for ferroptosis via the Fenton reaction

[DOI] [PMC free article] [PubMed] [Google Scholar] 181.Ball L., Accotto G.P., Bechtold U., Creissen G., Funck D., Jimenez A., Kular B., Leyland N., Mejia-Carranza J., Reynolds H., et al

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