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The current state of the osteoarthritis drug development pipeline: a comprehensive narrative review of the present challenges and future opportunities

Elevated intracellular iron levels facilitate the generation of ROS through Fenton chemistry, subsequently initiating lipid peroxidation reactions ( Compared with other forms of cell death such as apoptosis, necrosis, and autophagy, ferroptosis exhibits distinct molecular mechanisms and biological features ( Table 1 ): (1) Iron Dependence: Ferroptosis is uniquely triggered by elevated intracellular iron levels, differentiating it from other cell death modes

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For all practical research purposes, you can assume the final volume is equal to the volume of bacteriostatic water you added

Consent for publication All participants involved in the study have provided their informed consent for publication of the results

For BPC-157, it includes limited human reports with small sample sizes