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The deficiency of free CoA limits the efficiency of the Krebs cycle in activating anaerobic glucose metabolism (which inhibits pyruvate dehydrogenase activity, which is responsible for the conversion of pyruvate to acetyl-CoA in aerobic glucose metabolism in cells of the human organism), causing an increase in the concentration of toxic lactate in tissues [58,78,79]

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Interestingly, central obesity appeared to decrease slightly in individuals with exceptionally high serum uric acid concentrations

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The Phase I research by Wessells et al