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Clinical Trials on Dual GLP-1/GIP Agonists Tirzepatide: Combining GLP-1 and GIP for Enhanced Weight Loss Tirzepatide is a dual glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptor agonist developed to enhance weight loss beyond that achieved with GLP-1 receptor agonist monotherapy

184 However, CX3CR1-deficient mice show significant resistance to stress-induced depressive-like behaviors

GLP-1 and GIP stimulate insulin secretion from these cells in a glucose-dependent manner, meaning that insulin release intensifies in response to heightened plasma glucose levels

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That is especially important for active adults and patients trying to improve long-term physical function