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Our results indicated that neither GHK nor GHK-Cu showed cytotoxic activity after 72 h exposure to HaCaT cells

10.1016/j.intimp.2023.111290 41 KessasK.LounisW.ChouariZ.VejuxA.LizardG.KharoubiO

Smoke is another exogenous source of AGE and it has in fact been seen that the serum levels of AGE in smokers are significantly higher compared to non-smokers [46]

Nicotinamide and allopurinol seem to be effective in reducing the inflammation of soft tissue but the data sustaining this conclusion were obtained in a rather small sample of GO patients affected with both moderate-to-severe and mild GO ( in vitro results on the use of pentoxifylline are promising, but clinical studies provided conflicting results ( in vitro findings reported above, one can speculate that quercetin and -carotene might be the most promising, but clinical trials are needed to confirm this hypothesis

Cellular repair is a slow biological process that cannot be rushed

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