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For a disease that kills one in four patients despite treatment and leaves half of survivors with permanent brain damage the convergence of results across three experimental systems, including a drug already in global clinical use, is the strongest translational case the field has had

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Higher doses of Isotretinoin can sometimes lead to more pronounced side effects

Experimental studies have also identified SDF-1 as a mediator of pain and neovascularization in diabetic neuropathy [29, 30]

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