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Overall, compared with the large and growing amount of pre-clinical and mechanistic evidence highlighting the reward-modulating and thus potentially anti-addictive properties of GLP-1RAs, only a few studies have investigated thus far the potential use of these medications in clinical populations with alcohol- or other substance-use disorders

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Overall health care spending in the state in surpassed the state governments cost containment benchmark for four consecutive years as of 2024, according to a Center for Health Information and Analysis report

Although an endogenous OXM receptor has not been identified, OXM exerts weak agonist activity on GLP-1R (106) and the glucagon receptor (GCGR) (107)