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[DOI] [PMC free article] [PubMed] [Google Scholar] 203.Yancy W.S., Jr., Crowley M.J., Dar M.S., Coffman C.J., Jeffreys A.S., et al

Five clinical trials in type 2-diabetic subjects (SURPASS 15) have shown that tirzepatide at 515 mg per week reduces both HbA 1c (1.24 to 2.58%) and body weight (5.411.7 kg) by amounts unprecedented for a single agent

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Healthcare providers should conduct comprehensive assessment including renal function, thyroid history, gastrointestinal health, and cardiovascular status before initiating combination therapy, with ongoing monitoring to ensure safety and efficacy

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