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Although the exact mechanisms by which smoking causes diseases are unclear, chronic inflammation is the main factor in the development of diseases relevant to smoking such as lung cancer, heart disease, COPD, and asthma [61, 62]

The primary toxicity of nicotine is sustaining addiction, and it is doubtful that very small differences in nicotine exposure, as were seen in our study, would have any meaningful effect on the addiction potential of the cigarettes

The Centers for Disease Control and Prevention has warned that bidis contain higher levels of nicotine, tar and carbon monoxide than conventional cigarettes

Massey and M

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Healthier individuals may eliminate nicotine more efficiently