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According to the article, nicotine is mainly a potent activator of midbrain dopamine reward pathway, and its action on the locus ceruleus activates awareness, provocation, and attentiveness with anxiety activity, making nicotine users more attentive and creating dependency similar to other addictive drugs like cocaine and heroin

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In here it was revealed that older adults who smoked tobacco had a 24 percent significantly higher likelihood to have cognitive impairment with reference to older adults who did not smoke [OR: 1.24, CI:1.021.49]