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The health effects of e-cigarettes are still being studied but nicotine addiction , harmful chemical additives , battery explosions causing injury , acute nicotine poisoning and vaping related lung injury have all been linked to use of e-cigarettes and vaping

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Achieving this can be challenging and great care has to be given when choosing exposure dose ranges, which can be based on (i) animal to human exposure conversion factors for in vivo studies [82] and (ii) human data for in vitro studies [83, 84]

In many parts of the world, pants is a general term for lower garments that cover the legs, while trousers often refers to more formal or structured pants