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Nicotine binds to and activates the nicotinic acetylcholine receptors (present abundantly in the central and peripheral nervous systems) and thus increases intracellular calcium and leads to downstream activation of cAMP response element-binding protein, a key transcription factor for many genes (Shen and Yakel, 2009)

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It is a more dangerous form of cocaine and can cause severe respiratory problems, depression, damage to the heart and liver, malnutrition, as well as aggressive and paranoid behaviour.

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