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Smokers respond less favorably to non-surgical and surgical periodontal treatment, and there is a greater risk of recurrence in smoker patients with periodontitis 26

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E-liquids typically contain nicotine (though some claim to be nicotine-free), flavorings, propylene glycol, and vegetable glycerin

12 , 962963 (1961) Stanley, R.P.: Enumerative combinatorics

That has an economic cost, of course