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Event: 1635: Increase, DNA strand breaks Short Name: Increase, DNA strand breaks AOPs Including This Key Event Stressors Biological Context Domain of Applicability Taxonomic Applicability Life Stage Applicability Sex Applicability Taxonomic applicability: DNA strand breaks are relevant to all species, including vertebrates such as humans, that contain DNA (Cannan & Pederson, 2016)

Cells were washed and incubated with Cy-3 or Cy-5 conjugated secondary antibodies (Jackson ImmunoResearch Laboratories, West Grove, PA and Thermofisher)

Azevedo LF, Karpova NN, Rocha BA, Barbosa F, Gob GC, Carneiro MFH (2023) Evidence on Neurotoxicity after Intrauterine and Childhood Exposure to Organomercurials

Addressing hyperpigmentation: Gluteq targets common skin conditions such as melasma and hyperpigmentation

Setria is the gold-standard, clinically studied form of glutathione

32, 33 found significantly increased 3-nitrotyrosine (3-NT), a marker of oxidative protein damage, while noting a trend of increased 8-oxo-deoxyguanosine (8-oxo-dG), a marker of oxidative DNA damage