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Neurological symptoms are particularly characteristic and may include: Paraesthesia (pins and needles) in the hands and feet Numbness or altered sensation in the extremities Difficulty with balance and coordination, often due to spinal cord involvement (subacute combined degeneration) Memory problems and cognitive impairment Mood changes, including depression and irritability Visual disturbances (rare and usually in advanced deficiency) Haematological manifestations commonly present as symptoms of anaemia: Persistent fatigue and weakness Breathlessness, particularly on exertion Palpitations or rapid heartbeat Pale or jaundiced (yellowish) skin Glossitis (sore, red tongue) Mouth ulcers Additional signs may include: Unexplained weight loss Diarrhoea or constipation Loss of appetite Muscle weakness The severity and combination of symptoms vary considerably between individuals

doi: 10.3389/fcimb.2021.663131 27 AndersSTanakaMKinneyDK

Chronic conditions require longer exposure, typically four to eight weeks minimum before meaningful progress occurs

An immunohistochemical approach to differentiate hepatic lipidosis from hepatic phospholipidosis in rats

Patients should always follow the dosing instructions provided by their healthcare provider