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Start at the lowest dose, titrate slowly, monitor frequently, and maintain close communication between all prescribers

Studies indicate tirzepatide and semaglutide are most effective, followed by dulaglutide and liraglutide

These barriers can delay treatment initiation by weeks or months

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Regulatory agencies like the FDA require strong safety databases for drugs that will be prescribed to millions of people, and a trial of this size provides the statistical power needed to detect both efficacy signals and uncommon adverse events